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KMID : 1020220110110040419
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Journal of Korean Society of Dental Hygiene
2011 Volume.11 No. 4 p.419 ~ p.426
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Beneficial effect of vitamin K on bone health
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Jang Young-Ho
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Abstract
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Originally, vitamin K was defined as a factor for blood coagulation. Now more attention is focused on vitamin K for bone metabolism and bone health. Vitamin K is a coenzyme for glutamate carboxylase which converts glutamate residues to γ-carboxyglutamate(Gla) residues. Gla residues have calcium binding ability and bound to hydroxyapatite crystals in bone. Vitamin K promotes the carboxylation of osteocalcin and matrix Gla-protein, vitamin K-dependent proteins and improves bone mineral density and bone mass. Vitamin K deficiency causes reductions in bone mineral density and increases the risk of osteoporotic bone fractures, resulting from undercarboxylated osteocalcin. This paper is to provide a brief information of vitamin K and its role in bone health.
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KEYWORD
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osteocalcin, bone health, osteocalcin, vitamin K
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FullTexts / Linksout information
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Listed journal information
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